THE JOURNAL / Polynucleotide Treatment vs Profhilo: Which is Right for your Skin?
Polynucleotide Treatment vs Profhilo: Which is Right for your Skin?
By: Amanda Azzopardi
11/11/26
Polynucleotides and Profhilo are part of a new generation of regenerative injectable treatments that offer skin rejuvenation and anti-ageing benefits. Polynucleotide treatment and Profhilo have some key differences. Profhilo is essentially an injectable moisturiser that penetrates deep into the tissues to provide intense hydration. Polynucleotides stimulate the body’s own healing response for skin renewal. Read … Polynucleotide Treatment vs Profhilo: Which is Right for your Skin?
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Polynucleotides and Profhilo are part of a new generation of regenerative injectable treatments that offer skin rejuvenation and anti-ageing benefits.
Polynucleotide treatment and Profhilo have some key differences.
Profhilo is essentially an injectable moisturiser that penetrates deep into the tissues to provide intense hydration. Polynucleotides stimulate the body’s own healing response for skin renewal.
Read on to discover more about these innovative treatments that could help to restore youthful-looking skin.
What does Profhilo offer?
Profhilo contains ultra-pure hyaluronic acid at a very high concentration. Not only does Profhilo offer deep skin hydration, but it can also stimulate collagen and elastin production, resulting in skin regeneration benefits for ageing skin.
The benefits of Profhilo
The specific benefits of Profhilo include:
- Deep hydration
- Subtle improvements in skin laxity
- Smoother skin texture
- Increased skin firmness and skin elasticity
Profhilo requires multiple tiny injections under the skin, allowing the hyaluronic acid to disperse throughout the tissues and improve skin quality in the treated areas. The injections are delivered at five injection sites on each side of the face, specifically chosen to avoid major blood vessels and to maximise the spread of the hyaluronic acid.
The number of treatment sessions required
We advise an initial course of 2 to 3 sessions, spaced 4 weeks apart. Many patients choose to have maintenance treatments after 6- 9 months.
The development of results
Patients may notice improved hydration and a subtle glow the week after treatment, but optimal results typically develop a few weeks later as increased collagen and elastin production firms and smooths the skin.
How do Polynucleotide Treatments benefit skin quality?
Polynucleotides are highly purified DNA fragments, usually derived from fish, making them unsuitable for patients with skin allergies. When injected into the skin, they stimulate fibroblasts, encouraging collagen and elastin production and supporting the body’s natural regenerative process.
The benefits of treatment with polynucleotides
The benefits of polynucleotides include:
- Improvement in fragile skin areas like under the eyes
- Reduction in fine lines and wrinkles and crepey skin
- Improvement in the appearance of acne scarring and other minor imperfections
- Reduction in skin inflammation
The number of treatment sessions required
The initial course will depend on the treatment required but is typically 3 or 4 sessions. Maintenance sessions are often needed after 12-18 months.
The development of results
The results of polynucleotides treatment begin to show 2 to 4 weeks after the first session, with an improvement in skin hydration and radiance. Full skin rejuvenation is a gradual process that takes up to 12 weeks as skin firmness and elasticity develop with the increased levels of collagen and elastin.
Polynucleotides vs Profhilo: Longevity of results
The benefits of both treatments last around 6 – 9 months.
Are these injectable treatments the same as dermal fillers?
No. Both polynucleotides and Profhilo focus on improving skin quality and skin health. Unlike traditional dermal fillers, they do not add volume and cannot be used to contour the facial features.
Key Features of Profhilo and Polynucleotides
| Feature | Profhilo | Polynucleotides |
| Main Ingredient | Ultra-pure, highly concentrated Hyaluronic Acid (HA) | Purified DNA fragments (typically derived from salmon or trout) |
| Primary Action | Deep hydration and “bio-remodelling” by drawing in water and supporting collagen/elastin | Supports natural cell renewal in the skin, improving texture and firmness. |
| Best Suited For | Overall dullness, dehydrated skin, and mild skin laxity | Fragile or thin skin with fine lines or a crepey texture. |
| Key Treatment Areas | Face (excluding forehead), neck, décolletage, and hands | Delicate zones like the under-eye area (peri-orbital), forehead, full face, and neck |
| Under-Eye Safety | Not suitable for close under-eye injection (can attract too much water and cause puffiness) | Designed to refresh the fragile under-eye skin. |
| Typical Protocol | 2 sessions spaced 4 weeks apart | 3 to 4 sessions spaced 2 to 4 weeks apart |
| Results Timeline | Noticeable improvement in hydration and “glow” within 1 to 2 weeks | Gradual; improvements build progressively over several weeks to months |
| Longevity | Typically lasts around 6 months | Typically lasts 6 to 9 months (or up to a year depending on the product) |
Profhilo vs polynucleotides: which is best for me?
The choice between treatments will depend on your skin concerns and the type of skin rejuvenation you are looking for.
Why not book a consultation at our friendly and highly regarded clinic so that Amanda can discuss a treatment plan with you?
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